David Geffen School of Medicine at UCLA

Undergraduate Education	Stanford University
Medical Education	Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program
Internship	Saint Vincent's Medical Center
Residency Training	University of California, Los Angeles Dermatology
Board Certification	Dermatology
Clinical Interest	Melanoma
Research Interest	Genetic underpinning of human melanoma, with an emphasis on malignant initiation in the skin

Selected Publications

1. R.S. Lo and O. N. Witte (2007) Proper skin architecture enables delineation of a multi-step, genetic pathway in human melanocytic tumorigenesis, Submitted.

2. R.S. Lo , D. Wotton, and J. Massagué (2001) Ras signaling controls the Smad transcriptional corepressor TGIF, EMBO Journal, 20, 128-136.

3. J. Massagué, S.W. Blain, and R.S. Lo (2000) TGF-b signaling in growth control, cancer and heritable disorders, Cell, 103, 295-309.

4. D. Wotton, R.S. Lo , L. C. Swaby and J. Massagué (1999) Multiple modes of repression by the Smad transcriptional corepressor TGIF, Journal of Biologic Chemistry, 274, 37105-37110.

5. B. Pasche, P. Kolachana, K. Nafa, J. Satagopan, Y-G Chen, R.S. Lo et. al., (1999) TbR-I(6A) is a candidate tumor susceptibility allele, Cancer Research, 59, 5678-5682.

6. R.S. Lo and J. Massagué (1999) Ubiquitin-dependent degradation of TGF-b-activated Smad2, Nature Cell Biology, 1, 472-478. (News & Views in the same issue)

7. D. Wotton, R.S. Lo , S. Lee and J. Massagué (1999) A Smad transcriptional corepressor, Cell, 97, 29-39.

8. Y-G Chen, A. Hata, RR.S. Lo , D. Wotton, Y. Shi, N. Pavletich and J. Massagué (1998) Determinants of specificity in TGF-b signal transduction, Genes & Development, 12, 2144-2152.

9. R.S. Lo , Y-G Chen, Y. Shi, N. P. Pavletich and J. Massagué (1998) The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-b receptors, EMBO Journal, 17, 996-1005.

10. Y. Shi, A. Hata, R.S. Lo , J. Massagué, and N. Pavletich (1997) A structural basis for mutational inactivation of the tumour suppressor Smad4, Nature, 388, 87-93. (News & Views in the same issue)

11. Hata, RR.S. Lo , D. Wotton, G. Lagna, and J. Massagué (1997) Mutations increasing auto-inhibition inactivate the tumour suppressors Smad2 and Smad4, Nature, 388, 82-87. (News & Views in the same issue)