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The Roger S. Lo Laboratory addresses key challenges in the development of novel melanoma therapeutics. We have focused on how BRAF mutant melanomas acquire late resistance to BRAF inhibitors and how the BRAF inhibitors induce secondary neoplasms. Our current research tackles layers of complexity during the evolution of resistance to targeting of a key melanoma-addicted oncogene such as BRAF. These complexities include signaling and epigenetic reprogramming, melanoma dormancy, and the master-regulators of such melanoma phenotypic plasticity. We seek to also understand the functional interface between melanoma and its tumor-infiltrating neighboring cells, including immune-regulatory and immune cells. Finally, we look for therapeutic opportunities from our pre-clinical and clinical tissue correlative studies and promote clinical trial testing of novel therapeutic concepts.

THE ROGER S. LO LABORATORY IN THE NEWS

Click the links below to read more about the Roger S. Lo Laboratory:

American Association for Cancer Research - Insight Into Melanoma Drug Resistance Pathways Identifies Potential New Treatment Option

UCLA News - UCLA research could enhance treatment for drug-resistant melanoma

Newswise - Cancer Researchers Translate New Laboratory Findings to Enhance Melanoma Treatment

The ASCO Post - New Studies Provide Insight Into Melanoma Drug Resistance Pathways and Strategy for Obtaining Durable Responses

EurekAlert! - SU2C researcher identifies potential treatment option for melanoma

Examiner - Two new UCLA studies report advances in melanoma research

Family Health Helper - Combinatory therapy may be effective in suppressing drug resistance in treatment of melanoma

eCancer News - Insight into melanoma drug resistance pathways identifies potential new treatment option

Health, Wellness, Fitness - Combination therapy may be effective in supressing drug resistance in treatment of melanoma

 

 

We are affiliated with the Department of Medicine/Division of Dermatology and the Jonsson Comprehensive Cancer Center (Tumor Cell Biology Program)

Please contact us if you would like to learn more about our work and current training and employment opportunities. 

(1) Postdoctoral Fellow Position Available

A postdoctoral position is open focused on melanoma research toward our understanding of the mechanisms of acquired resistance to targeted therapies (B-RAF inhibitors) using integrated genomics.  We are affiliated with the Department of Medicine/Division of Dermatology, the Department of Molecular and Medical Pharmacology, and the Jonsson Comprehensive Cancer Center (Tumor Cell Biology Program) at the University of California, Los Angeles.  

The ideal candidates must have extensive experience handling RNA, DNA, and protein.  His or her skill set should include molecular cloning, immunohistochemistry, immunoprecipitation, FACS analysis, immuno-blotting, mammalian cell culture, viral transduction, microscopy, and small animal work.  Strength in bioinformatic skills is a significant advantage.  Fluency in English and strong written and oral communication skills are pre-requisites.  US permanent residency or citizenship is not required although preferred.  Interested individuals should have at least one first-authored publication in a top-ranked peer-reviewed journal. 

(2) Postdoctoral Fellow (Bioinformatics-focused)

This position is open immediately in the Lo Laboratory, which is focused on melanoma research in the following thematic areas:

  • Discovering somatically mutated genes in melanoma using exon capture and next-generation sequencing and studying these genes in the pathogenesis of melanoma.
  • Understand the mechanisms of primary and acquired resistance to targeted therapies (including B-RAF inhibitors) using integrated genomic technologies.

We are affiliated with the Department of Medicine/Division of Dermatology, Department of Molecular and Medical Pharmacology, and the Jonsson Comprehensive Cancer Center (Tumor Cell Biology Program) at the University of California, Los Angeles.

The ideal candidates must have experience with RNA expression profiles (GO, GSEA, etc.), genomic DNA copy number variation data, and tools of handling large data sets.  Experience with analysis of highly parallel sequencing data a plus, but this may be acquired via training by our current postdoctoral fellow.  Fluency in English and strong written and oral communication skills are pre-requisites; US permanent residency or citizenship is not required.  Interested individuals should have at least one first-authored publication in a peer-reviewed journal.

PLEASE NOTE:

Interested individuals should forward a CV along with three letters of recommendation, one of which from the doctoral thesis advisor or current employer to rlo@mednet.ucla.edu.

 Posting date May 2, 2011.