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The Roger S. Lo Laboratory is focused on melanoma research in three thematic areas:

  • Discovering somatically mutated genes in melanoma using exon capture and next-generation sequencing and studying these genes in the pathogenesis of melanoma.
  • Dissecting oncogene co-dependent survival networks in melanoma using V600EB-RAF as a prototypic melanoma oncogene and siRNA library as a discovery tool.
  • Understand the mechanisms of primary and acquired resistance to targeted therapies (including B-RAF inhibitors) using integrated genomic technologies.

We are affiliated with the Department of Medicine/Division of Dermatology and the Jonsson Comprehensive Cancer Center (Tumor Cell Biology Program)

Please contact us if you would like to learn more about our work and current training and employment opportunities. 

(1) Postdoctoral Fellow Position Available

A postdoctoral position is open focused on melanoma research toward our understanding of the mechanisms of acquired resistance to targeted therapies (B-RAF inhibitors) using integrated genomics.  We are affiliated with the Department of Medicine/Division of Dermatology, the Department of Molecular and Medical Pharmacology, and the Jonsson Comprehensive Cancer Center (Tumor Cell Biology Program) at the University of California, Los Angeles.  

The ideal candidates must have extensive experience handling RNA, DNA, and protein.  His or her skill set should include molecular cloning, immunohistochemistry, immunoprecipitation, FACS analysis, immuno-blotting, mammalian cell culture, viral transduction, microscopy, and small animal work.  Strength in bioinformatic skills is a significant advantage.  Fluency in English and strong written and oral communication skills are pre-requisites.  US permanent residency or citizenship is not required although preferred.  Interested individuals should have at least one first-authored publication in a top-ranked peer-reviewed journal. 

(2) Postdoctoral Fellow (Bioinformatics-focused)

This position is open immediately in the Lo Laboratory, which is focused on melanoma research in the following thematic areas:

  • Discovering somatically mutated genes in melanoma using exon capture and next-generation sequencing and studying these genes in the pathogenesis of melanoma.
  • Understand the mechanisms of primary and acquired resistance to targeted therapies (including B-RAF inhibitors) using integrated genomic technologies.

We are affiliated with the Department of Medicine/Division of Dermatology, Department of Molecular and Medical Pharmacology, and the Jonsson Comprehensive Cancer Center (Tumor Cell Biology Program) at the University of California, Los Angeles.

The ideal candidates must have experience with RNA expression profiles (GO, GSEA, etc.), genomic DNA copy number variation data, and tools of handling large data sets.  Experience with analysis of highly parallel sequencing data a plus, but this may be acquired via training by our current postdoctoral fellow.  Fluency in English and strong written and oral communication skills are pre-requisites; US permanent residency or citizenship is not required.  Interested individuals should have at least one first-authored publication in a peer-reviewed journal.

PLEASE NOTE:

Interested individuals should forward a CV along with three letters of recommendation, one of which from the doctoral thesis advisor or current employer to rlo@mednet.ucla.edu.

 

Posting date May 2, 2011.